This study aims to develop an integrated and theoretically grounded framework to examine the impact of astrology-based content on the purchase behavior of Generation Z. This topic is significant both theoretically within the field of marketing and practically for brands; however, it has not yet been examined in a coherent and systematic manner. The present research is applied in terms of purpose and descriptive in terms of data collection, employing a mixed qualitative–quantitative approach. In the qualitative phase, a meta-synthesis method was used, encompassing the stages of search, appraisal, synthesis, reporting, and interpretation of detailed findings from prior studies. Data were collected through a review of existing documents and literature, with 26 scientific articles selected for analysis using content analysis techniques. Subsequently, thematic analysis was conducted through interviews with experts. Coding was performed manually and with the assistance of MAXQDA software. In the quantitative phase, the fuzzy cognitive mapping (FCM) method was employed. To calculate the degree of influence, susceptibility, and centrality index, the weights computed for 37 relationships were organized into a matrix and entered into FCMapper software. The results indicate that consumer interaction and engagement, as well as consumer attitudes toward the brand, exhibit the highest levels of influence, susceptibility, and centrality. In contrast, interaction with the campaign and characteristics of advertising content demonstrate the lowest levels across these indices.